When a woman reaches her late 40s or early 50s, the monthly menstrual cycle that controls her hormone levels and readies ova for insemination ceases. Her ovaries have been producing less and less estrogen, inciting physical and emotional changes across her body. Her underdeveloped egg follicles begin to fail to release ova as regularly as before. The average adolescent girl has 34,000 underdeveloped egg follicles, although only 350 or so mature during her life (at the rate of about one per month). The unused egg follicles then deteriorate. With no potential pregnancy on the horizon, the brain can stop managing the release of ova.